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Recreational drug use and the chronic use of certain pharmaceuticals, such as chemotherapeutic agents, further increase oxidative burden by interfering with normal mitochondrial processes [14, 15]

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Downstream DAMP-associated microglia activation results in the assembly of the classical NADPH oxidase on the plasma membrane, resulting in the release of superoxides into the extracellular space, where they contribute to neuronal damage (Della Bianca et al., 1999)

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