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Protein therapeutic molecules, including antibodies (Schmitt and Greten, 2021), metabolism-blocking proteins (Liu et al., 2017), enzymes (Yu et al., 2024), and apoptosis-inducing agents (Hu and Kavanagh, 2003) have also been successfully combined with engineered bacteria for targeted therapy of tumors (Table 1)

The key mismatch driver is the constitutive hyperactivation of the nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant pathway in tumor cells

(2020) developed a scaffold-free endometrial organoid model consisting of epithelial and stromal components that closely mimics the physiology of native endometrium

N Engl J Med 324(20):1385-93, 1991