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Int 21 , 378386 (2022)

In the brain, glutamate can be directly synthesized de novo by astrocytes or indirectly produced from glucose molecules through the actions of pyruvate dehydrogenase and astrocyte-specific enzyme pyruvate carboxylase (Krzyanowska Pomierny et al., 2014

doi: 10.1021/jf405820v

Ideally, the animal model should express the same kind of virus receptors, and the receptors should be distributed in similar anatomical locations to those of humans, such that they get infection via a similar route of transmission as do human beings (168)

Vertebrates accumulate sulfur in the range of approximately 610,000 mg/kg DW in both the liver and kidneys (Kitowski et al