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Methods: We constructed risk models that accurately predict the HCC progression using 101 machine learning algorithm combinations.TCGA and ICGC datasets were employed

Poon AIF, Sung JJY

9 Toxicology and side effects Current evidence reveals an intrinsic paradox between therapeutic efficacy and safety profiles of bioactive compounds - no identified pharmacologically active agent completely avoids non-specific off-target effects on healthy tissues ( in vitro study demonstrated that shikonin has potent cytotoxicity against 15 types of cancer cells through mitochondrial dysfunction and can induce apoptosis

doi:10.1097/00000658-198808000-00002

In this regard, it has been reviewed recently that systemic administration of the DHP isradipine suppresses cytosolic calcium transients, increases mitochondrial mass and lowers mitophagy in dopaminergic neurons 54