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10.1038/s41419-023-05978-8 155 LiC.DengX.XieX.LiuY.Friedmann AngeliJ

This process involves the release of chemokines by lung epithelial cells and macrophages, prompting neutrophils to interact with endothelial cells via adhesion molecules such as CD11b/CD18, ultimately crossing the vascular wall to infiltrate lung tissue (143).Infiltrating neutrophils release reactive oxygen species (ROS) and proteases, directly damaging lung structures and exacerbating inflammatory responses

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However, NPs usage has certain challenges, such as including ROS-induced toxicity, abnormal internalization into tissues, and aggregation