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Nrf2 promotes -glutamyl-peptide (GC) synthesis and inhibits ferroptosis caused by Cys 2 deficiency by regulating the catalytic subunit of glutamate-cysteine ligase (GCLC) [89]

These hub genes, particularly BCL-2, GSK3B, MAO-B, and MAO-A are critical players in the network as indicated by their topological metrics highlighting their central roles in apoptosis regulation, dopamine metabolism, and neuroprotection, underscoring the molecular mechanisms through which resveratrol might exert its beneficial effects in Parkinsons disease