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The count data were filtered to remove genes with low expression, transformed using the variance stabilizing transformation from the DESeq2 package (51), and then batch corrected using ComBat (52)

The compartmentation of cAMP signaling in the heart arises, in part, from specific signaling complexes which generate distinct cell responses, with AC5 and AC6 being central effectors to the formation and maintenance of these compartments

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Zinc deficiency appears to play a role not only in liver cancer outcomes but also in the risk of liver cancer development