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& Murcha, W.M.) 197210 (Springer New York, 2015)

In vitro studies clearly show that physiological but sublethal oxidative stress interferes with OPC differentiation without affecting cell viability, and high levels of ROS can induce OPC death

Overall, our study provides detailed mechanistic insights into AAs action on CLL B-cells and identified drug combination strategies that might enhance the efficacy of treating CLL B-cells