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doi:10.1155/2012/968040

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35, 36 Mice were weighed twice weekly to assess toxicity and killed when tumors reached 1500 mm 3 or they experienced any severe morbidity (that is, body weight 2, (b) a significant difference ( P 60% were considered to have low activity

Using this system, compound W478 was identified as a previously unobserved SHMT2 inhibitor, which is distinguished from previously reported inhibitors of SHMT2, such as antifolate analogues and pyrazolopyran derivatives, by virtue of its unique chemical structure

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