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PS Asymmetry in Biological Membranes PS, the most abundant negatively charged glycerophospholipid in eukaryotic membranes, is comprised of a glycerol backbone esterified at the sn -1 and sn- 2 carbons of the glycerol moiety with two fatty acyl chains of variable length and saturation, and a phosphate linkage at the sn -3 position (Figure 1)