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Opening a chloride channel will allow the negatively charged chloride ion to enter the cell and will reduce the electrical charge inside the cell (thereby hyperpolarizing it) and effectively render the neuron unresponsive to incoming stimuli that would otherwise depolarize the cell

The PI3K/Akt/mTOR pathway plays a crucial role in regulating autophagy in human cancers and serves as a vital detector of nutrient and growth factor rates [278, 279]

Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine

This is particularly important for GBM, where treatment responses can vary dramatically among patients