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FIGURE 2 Effect of Melatonin on Expression Levels of Genes Related to the Antioxidant Response Quantitative PCR was used for transcriptional analysis of certain genes implicated in endogenous antioxidant defense, such as CTA1 and CTT1 (catalase A and T, respectively), SOD1 and SOD2 (cytoplasmic and mitochondrial superoxide dismutase, respectively), GRX2 (glutaredoxin), and TRX2 (thioredoxin) and in glutathione metabolism, such as GSH1 (-glutamylcysteine synthetase), GLR1 (GR), GPX1 (glutathione peroxidase), and ZWF1 (glucose-6-phosphate dehydrogenase, which reduces NADP + to NADPH)

102 Fibroblast growth factor 1 (FGFR1) signaling is a key pathway in LMP1-mediated growth transformation

Future randomised controlled trials should specifically evaluate the effectiveness of novel AOMs for long-term weight management in older adults with obesity, carefully considering the impact on body composition and functional ability, as well as health economics

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