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PMID: 33933432

The problems are not hidden deep in some obscure and complex regulations, but rather the basics that everybody knows about

X., Kelley, C., & Winkel, C

Investigators noted that ACR20 response was statistically greater than placebo as early as 1 week after the first dose and was sustained through 24 weeks

Taken together, it is tempting to speculate that the mechanistic order is that high glucose stimulates an increase in PKA that subsequently inhibits G6PD activity and a resultant decrease in NADPH