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Notably, STAT3 and its downstream pathways, involving the upregulation of c-Myc, Bcl-xL, Cyclin D, S100A8/A9, and NOX2, along with cooperation with cytokines like IL-6, GM-CSF, and G-CSF, are implicated in MDSC accumulation and immunosuppressive mechanisms [347, 370372]

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In recent years, the incidence of PCOS was increasing (68), which could cause ratio imbalance of estrogen, insulin resistance, hyperinsulinemia, hyperandrogenemia, endometrial dysfunction, infertility, cardiovascular disease, and obesity (9)