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An NF-kappaB transcription-factor-dependent lineage-specific transcriptional program promotes regulatory T cell identity and function

TPO-deficient cultures were maintained in StemSpan SFEM II medium supplemented with IL-6, IL-9, and SCF (10 ng/mL each), supplemented without or with TPO 10 ng/mL, and 10 M BCT1028 (or v/v DMSO as control) every 24 h

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8991 As a net effect, the combination of high sensitivity of CD8 effector T cells with resistance of immunosuppressive Treg cells leads to suppression of anti-tumor immune response

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