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Abnormalities of Na + /K + ATPase (NKA) activity in epilepsy has been reported (Verkhratsky et al., 2019a,b), and the involvement of protein kinases and phosphatases in regulating such neuronal NKA activity is also evident (Mohan et al., 2019)

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Enzyme function is also compromised by copper deficiency, including that of copper-zinc SOD (Cu-Zn SOD), resulting in a weakened antioxidant defence system and increased vulnerability to oxidative stress, contributing to the development of atherosclerosis (103)