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It acts like a magnet for heavy metals, synthetic chemicals, and mycotoxins (the toxic compounds produced by certain types of mold)

doi:10.1042/bj2160503 Almeida EA, Bainy ACD, Loureiro APM et al (2007) Oxidative stress in Perna perna and other bivalves as indicators of environmental stress in the Brazilian marine environment: antioxidants, lipid peroxidation and DNA damage

Furthermore, there is increased variability of viral cellular tropism with the emergent SARS-CoV-2 variants, which include Alpha, Beta, Gamma, Epsilon, Eta, Iota, Kappa, 1.617.3, Mu, Zeta, and in particular, Delta and Omicron, as well as the various lineages of each variant [14]

Relief can last anywhere from a few months up to 18 months

Identifying the specific gene-expression changes responsible for this persistence is an open research direction