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Yet, it is possible that no tau imaging studies were found due to the known challenges for tau radiotracers, including off-target binding, and difficulties of radiotracers binding to tau aggregates since they form intracellularly (Marqui et al., 2017

35, R522R526

And the other is that components of the system, not all the components but actually the vast majority of the components are synthesized by our bodies

Indeed, most reactive cysteine thiols generally exist as inter-chain disulfide bridges