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CRC malignant cells display a high demand for iron to sustain their elevated proliferation rate however, the excess of iron and heme enables death mechanisms by ROS production and ferroptosis

The subsequent steps involve the incorporation of glycine, 2 N 10 -formyl-THF units, aspartate, and glutamine-derived amide groups

Additionally, oxidative stress can activate microglia and astrocytes, contributing to neuroinflammation and further neuronal damage [136, 149]

While the benefits can be rewarding, patient safety must always come first

This results in impaired macrophage polarization and excessive proliferation of hematopoietic stem cells