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This approach was chosen because knockouts and knockdowns of XOR in LLC-PK1 cells were not viable, which was not unexpected given that mouse knockouts of XOR are lethal ( The observed reduction in XO and ALDH2 activity by GTN ( Figure 9 ) appears have an impact on several metabolic pathways, most notably purine metabolism ( Figure 5 )

Type 1 diabetes, which is characterized by insulin deficiency, results in reduced cardiac glucose uptake and oxidation, as the hearts glucose regulation is primarily insulin dependent