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Availability: InStock
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Description

Treatment of Philadelphia chromosome positive (Ph+) chronic myelogenous leukemia in blast crisis and Ph+ acute leukemia with high dose cytosine arabinoside (HDARAC)

Mechanism of Action Detailed mechanism information available in research literature

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Currently, the related data about mechanism of anthraquinones-caused hepatotoxicity and nephrotoxicity is limited, which need further research

The cryo-EM structure of the active GLS2 filament bound to glutamine was obtained upon rapid cryo-cooling of the enzyme immediately following substrate addition (i.e., to preserve the filament), and has provided critical new insights into the catalytic mechanism