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Moderate glutathione synthetase deficiency leads to hemolytic anemia and metabolic acidosis, whereas patients with a more severe deficiency also develop 5-oxoprolinuria, recurrent bacterial infections, and progressive dysfunction of the central nervous system, including mental retardation and motor functional disturbances

In addition, glutamine is shown to protect against pathogen-induced intestinal damage in vivo

Numerous studies have highlighted the therapeutic potential of glutathione in mitigating inflammation and oxidative stress, both of which are prominent features of gut dysbiosis

Intralysosomal iron chelation protects against oxidative stress-induced cellular damage

Among collagen sources, marine-derived collagen peptides are most frequently studied in skin-related clinical trials and are often associated with favorable efficacy, possibly due to their amino acid composition and lower average molecular weight [94]