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This cellular demise can subsequently diminish ECM synthesis, which in turn, exacerbates the degradative changes within the IVD microenvironment, perpetuating a cycle that further compromises the viability of NPCs

Furthermore, the relevance of this to the pathogenesis of disease is controversial ( In the meantime, the majority of research on mitophagy in the nervous system has concentrated on the molecular pathogenesis and potential therapeutic targets, while there is considerable debate surrounding the targets of mitophagy, the exact mechanism of receptor-mediated mitophagy, and how to address it

A specimen from a cadaver of a Baker's cyst in popliteal space Baker's cyst on axial MRI with communicating channel between the semimembranosus muscle and the medial head of the gastrocnemius muscle Baker's cyst on MRI, sagittal image Baker's cyst on MRI, sagittal image Treatment [edit] Baker's cysts usually require no treatment unless they are symptomatic

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