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Zhu W, Buffa JA, Wang Z, Warrier M, Schugar R, Shih DM, et al

Zuojiong Gong, [email protected] These authors share first authorship This article was submitted to Metabolomics, a section of the journal Frontiers in Molecular Biosciences Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Cobalamin (vitamin B12)Vitamin B12 supports the function of the nervous system and thus contributes to normal mental function

In addition, bacteria belonging to the TMA-producing genera were still present after treatment with the tested compounds, excluding their bactericidal action

Reasoning that the enzymes encoded by these genes could be responsible for the utilization of l-carnitine and its conversion to BB (Figure 7C), we used comparative genomics tools to identify 3 other organisms that contain the caiTABCDE gene operon (Supplemental Figure 5), and assessed their ability to consume l-carnitine and produce BB (Figure 8)