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Because VEGFRs and FGFRs, targets of lenvatinib, exert various physiological effects partly through the mTOR signaling (Liu et al., 2021), it is plausible that lenvatinib also inhibits protein synthesis via the mTOR pathway

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No changes in the percentage of subjects with one deficit were observed, while the percentage decreased from six subjects (25%) to five subjects (20.8%) for those with two deficits

Since the above mechanisms may be limited to sarcopenia alone, it is still necessary to conduct further in-depth studies to determine whether the above mechanisms play a similar role in patients with coexisting COPD and sarcopenia

The severity and duration of symptoms can vary considerably, often leading to substantial impairment in daily functioning and quality of life