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Importantly, even within this single-patient setting, the platform consistently captured functionally meaningful differences in drug metabolism and therapeutic response, demonstrating its capacity to resolve patient-specific pharmacological heterogeneity

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study, a strong correlation between membrane permeabilization and antifungal activity of the tested peptides was found with the most significant changes in membrane integrity at 0.5 mol L 1 of purothionin, followed by 2 mol L 1 of cecropin B, a natural peptide from cecropia moth (Oard et al., 2004)