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Acknowledgements This work was supported by the National Science and Technology Council, Taiwan (grant number NSTC 111-2320-B-002-037-MY3 to F-JL) and National Taiwan University (grant numbers 110L7243, 111L7218, and 113L894803 to F-JL)

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In Bd , enolase has also been shown to be constitutively glutathionylated, however, in contrast to human lymphocytes, peroxide stress reduces the proportion of glutathionylated enolase in Bd (45)

However, rats given Nano ZT/Vit B12 demonstrated a significant shift toward the anti-inflammatory pathway and Th-2 dominance over Th-1, as evidenced by lower levels of IL-1, TNF- and IL-17 and higher levels of IL-4, indicating that Nano ZT/Vit B12 has an anti-inflammatory effect

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