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Mechanically, isoorientin increases the SIRT1 and SIRT6 expressions, promotes Nrf2 translocation, and activates the expression level of antioxidant enzymes, including HO-1 and NQO1 to inhibit the expression levels of NOX4 and ROS production, thereby reducing oxidative stress, alleviating mitochondrial dysfunction, and improving kidney injury of cisplatin-induced AKI mice

The question of whether you should take two supplements together is always an excellent one because nutrients never work alone in the body

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