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Thus it is not surprising that compounds that increase the activity of the P450 enzymes, such as caffeine[40, 41] and anticonvulsant drugs[42] also make APAP more hepatotoxic

doi:10.1007/s10517-006-0365-z

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Int J Mol Sci 18(6):1221 Jeelani R, Khan SN, Shaeib F, Kohan-Ghadr HR, Aldhaheri SR, Najafi T, Thakur M, Morris R, Abu-Soud HM (2017) Cyclophosphamide and acrolein induced oxidative stress leading to deterioration of metaphase II mouse oocyte quality