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That belief shaped clinical decisions, scared men away from treatment, and - as it turns out - was built on a far shakier scientific foundation than most people realized

Two physiological features of this pathway shape how genetic variation expresses itself

As inhibition of the proteasome has been shown to result in upregulation of short-lived proteins, we investigated expression levels and the ubiquitination status of NOXA and MCL-1, two proteins of the BCL-2 family with a rapid turnover