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Okay, what is the overall net effect

We hypothesized that as oxidative stress and hyperglycemia are major etiologic and pathologic factors of diabetes mellitus, then the antioxidant enzyme, Glutathione-S-Transferase (GST) in red blood cells, are likely to have a role in the glycation of Hb in diabetic patients

CX: Writing original draft, Visualization, Data curation

Proc Natl Acad Sci USA 94(5):19671972 Hess B, Kutzner C, Van Der Spoel D, Lindahl E (2008) GROMACS 4: algorithms for highly efficient, load-balanced, and scalable molecular simulation