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Glick, HA

When GPX4 activity diminishes, lipid peroxidation proceeds unimpeded, consequently triggering ferroptosis (22)

Short-term hyperhomocysteinemia-induced oxidative stress activates retinal glial cells and increases vascular endothelial growth factor expression in rat retina

These types of chromosome aberrations are the consequence of asymmetrical chromosome translocations where the genetic material is recombined in what has been termed an illegitimate manner (e.g., a chromosome containing an extra centromere)

In this regard, substituents include oxo, halogen, heterocycle, CN, OR x , NR x R y , NR x C(O)R y , NR x SO 2 R y , C(O)R x , C(O)OR x , C(O)NR x R y , SO n R x and SO n NR x R y , wherein n is 0, 1 or 2, R x and R y are the same or different and independently hydrogen, alkyl or heterocycle, and each of said alkyl and heterocycle substituents may be further substituted with one or more of oxo, halogen, OH, CN, alkyl, OR x , heterocycle, NR x R y , NR x C(O)R y , NR x SO 2 R y , C(O)R x , C(O)OR x , C(O)NR x R y , SO n R x and SO n NR x R y