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Recent studies have indicated that p38 MAPK-dependent regulation is critical to promote longevity via supporting neuronal integrity, epidermal lysosomal structures and regulating innate immune responses 27,45

In the occupational context, the difference between idiopathic and chemical-induced vitiligo is not negligible, particularly when the individual suffering from the idiopathic form is exposed to chemical or physical agents also in the workplace

and NETs, in turn, is a known trigger for coagulation and blood vessel occlusion [359], and also involve significant erythrocyte pathologies, specifically related to rheology and oxygen carrying capacity and ultimately resulting in ischemia-reperfusion injury [352]