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doi:10.12998/wjcc.v10.i24.8735

For instance, in CSCs with a CD44v3 high /ALDH1 high phenotype, master transcriptional factors Oct4, Sox2 and Nanog were detected to be overexpressed at the mRNA and protein levels ( Further investigations into the role of CD44v3 in apoptosis regulation unveiled that the knockdown of CD44v3-containing isoforms mediates the reduction of PI3K, pAKT, pERK, pSTAT3 and Bcl2 protein levels, triggering apoptotic signaling and G0/G1 phase arrest in bladder cancer cells (Figure 5D