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At the ovarian level, receptor-mediated uptake and intracellular handling further favor DHA incorporation into the granular yolk layer, where it accumulates predominantly within phospholipid fractions

However, its clinical application is limited owing to oral toxicity, gastrointestinal toxicity, leukopenia and thrombocytopenia (75)

However, the role of AMPK has been challenged and might only account for indirect changes in hepatic insulin sensitivity

APOE4 derived from astrocytes leads to blood-brain barrier impairment