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315 (6), F1714F1719

It follows that iron metabolism and mean cell hemoglobin concentration, as well as genetic or other factors regulating them, such as blood donation frequency or repletion 74 , could contribute to inter-donor heterogeneity in hemolytic propensity and RBC susceptibility to hemolysis in general, making our findings relevant beyond transfusion medicine

These findings suggest that Tet2 is a transcriptional gene associated with macrophage NLRP3 inflammasomes and promoting its overexpression in macrophages could serve as a potential therapeutic approach to mitigate the inflammatory response in HUA (34)

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[PubMed: 3028512] 256