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Ferritin, which stores excess iron in the cellular iron pool, exerts a universal anti-iron dependent death effect (Ma et al., 2022)

What's the dose in trials

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Pharmacodynamic (PD) biomarkers are defined as the biological response to a drug treatment (Sawyers 2008) and either are treatment specific or may represent endogenous phenotype changes in a subject due to a drug treatment (Beger and Colatsky 2011)