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10.1128/IAI.01418-15

Kamath RS, Martinez-Campos M, Zipperlen P, Fraser AG, Ahringer J (2001) Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans

HSCs are the seed cells of the hematopoietic system, and their senescence is the core of hematopoietic system aging

Because glutathione is broken down in the gut when taken orally, IV administration bypasses this loss, theoretically delivering more intact glutathione to tissues