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doi:10.1016/j.dsx.2021.102275 Menne J, Dumann E, Haller H, Schmidt BMW

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Novo Nordisk files for FDA approval for CagriSema, the first once-weekly combination of GLP1 and amylin analogues owenhaskins Dec 19, 2025 2 min read Novo Nordisk has submitted a New Drug Application (NDA) to the FDA for once-weekly CagriSema (cagrilintide 2.4 mg and semaglutide 2.4 mg) injection, to be used with a reduced-calorie diet and increased physical activity, to reduce excess body weight and maintain weight reduction long term in adults with obesity or overweight in the presence of at least one weight-related comorbid condition

In conclusion, oxidative stress acts as a catalyst for deterioration of AD by augmenting MMP activation, thereby reshaping the ECM and aggravating degradation and remodeling of aortic wall