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This cascade leads to neuronal apoptosis and energy deficits, particularly in the prefrontal cortex and hippocampus ( 4.3 Excitotoxicity Synthetic cathinones disrupt glutamatergic signaling by enhancing glutamate release and impairing astrocytic uptake (Zhang and Bhavnani, 2006)

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Regional differences in the expression of ferroptosis regulators, such as GPX4, system Xc , or FSP1, and their heterogeneous expressions in different cell types likely underlie these distinct vulnerabilities