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The typical regimen involves: Loading dose for patients without neurological involvement : Hydroxocobalamin 1mg intramuscularly three times weekly for two weeks [13] [10] Loading dose for patients with neurological involvement : Hydroxocobalamin 1mg on alternate days until no further improvement, then Maintenance therapy : 1mg every two to three months (or every two months if neurological involvement) Lifelong maintenance therapy is necessary for irreversible causes such as pernicious anaemia or following gastric surgery

Apparatus UV-visible adsorption spectra were recorded on a U-3900H UVVis Spectrophotometer (Hitachi, Japan) at room temperature using a 500-L black-body quartz curette with 1-cm path length

Effects of Vitamin E on seizure frequency, electroencephalogram findings, and oxidative stress status of refractory epileptic patients

223 European Medicines Agency