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The animal experiment results demonstrated that butyrate plays a key immunomodulatory role in SLE by targeting B cells through epigenetic mechanisms (156, 157)

For instance, an ingredient such as azelaic acid, a natural acid found in yeast, could help reduce redness or dark spots

88,89 Lipoatrophy usually occurs in the patient's buttocks, limbs, and face, whereas lipohypertrophy is characterized by visceral fat accumulations, or fat accumulations in the abdomen, mid-upper neck, mammary area, and/or above the pubic region

Therefore, developing local, controllable, and reversible therapeutic methods holds greater clinical advantages, but this largely depends on the development of more advanced delivery systems and precise monitoring protocols