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Furthermore, the NLRP3 inflammasome and cyclic GMP-AMP synthase-STING pathway, which are associated with increased mitochondrial damage and respiratory stress, are activated in MS (133,134)

Primary research: Mitochondrial dysfunction, Barth syndrome, heart failure, age-related mitochondrial decline Mechanism: Binds cardiolipin in the inner mitochondrial membrane, stabilizing electron transport chain function and reducing reactive oxygen species Regulatory status: FDA-approved (Forzinity) for Barth syndrome

Qiu et al., 2018), CCl4 (Teraoka et al., 2012

Insulin concentration was determined according to manufacturer protocol

A possible function for StaufenC in antiviral defense has not been explored yet