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Dexamethasone, a synthetic glucocorticoid, may impede antibiotic permeability by tightening the BBB in the setting of meningitis

But the two were studied in different people, for different purposes, with different endpoints, over different time frames so a direct numeric comparison is not valid

Despite the critical importance of solubility data for improving the bioavailability of poorly soluble drugs, such data are often scarce in the literature due to the time and cost associated with experimental measurements 28,29

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