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NAD + acts as a cofactor through its interplay with NADH, playing an essential role in many enzymatic reactions of energy metabolism, such as glycolysis, oxidative phosphorylation, fatty acid oxidation, and the TCA cycle

Palpitations and anaphylaxis occur in a tiny percentage of patients

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This exceptional BBB permeability stems from its relatively small molecular weight of 750 Da and specific structural modifications that allow passive diffusion across endothelial tight junctions