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the avenanthramides are an extract of one or more of Avena sativa, Pieris brassicae, Pieris rapae, or Dianthus caryophyllus

Curcumin has been shown to re-polarize these M2-like macrophages towards an M1-like phenotype, which is associated with anti-tumor activity and pro-inflammatory cytokine production

It brightens the complexion, reduces the appearance of dark spots and fine lines, and restores the skin's youthful radiance

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Integrated preclinical to first-in-human to indication-specific randomized clinical trials (RCTs) would be ideal candidates to combine mechanistic readouts (local drug/metabolite concentration, biofilm imaging, single-cell viability) with clinical readouts and, in advanced preclinical studies, local drug/metabolite concentrations