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Biomed Pharmacother 2003

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Blood-brain interfaces: relevance to cerebral drug metabolism

We can get a sense of this if we look at the death-response curve: As Campbell and Dunaif noted, The total dose for the highest dose group (4.0 mg/kg) approaches the median lethal dose of 5.0 mg/kg for male F344 rats. The median lethal dose, or LD 50 , is the dose required to kill half the animals

Certain oncogenic mutations result in inactivation of apoptosis during tumor initiation and progression, and many studies have aimed to develop anticancer agents that promote the effective elimination of cancer cells via apoptosis