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Among the many putative ncRNA-IGF pathways discussed in this review, some are supported by patient survival analyses and tissue investigations

Additionally, the triglyceride-glucose (TyG) index, a measure of the relationship between fasting plasma TG and glucose levels (259, 260), was independently linked to a higher prevalence of depression among T2DM patients, as reported by Jiaju Ren et al

Wiley Interdiscip Rev Syst Biol Med (2020) 12(4):e1483

251 Notably, PHDs use iron, ascorbate, oxygen, and 2-oxoglutarate to hydroxylate and inhibit HIF1, while ROS disrupt these interactions, causing HIF1 accumulation

However, glutathione depletion results in GPX4 inactivation, which subsequently increases lipid peroxidation and ultimately induces ferroptosis (Zhang et al., 2022)