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Extracellular NAMPT and NAPRT: Adipocytokines and DAMPs In addition to a direct effect on NAD and its metabolites, the enzymes involved in synthesis of NAD also have important extracellular functions, as summarized in Figure 3

Gln is the most abundant amino acid in the human body, and it not only provides essential energy and biosynthetic raw materials for tumor cells, but is also an important substance through which tumor cells maintain redox homeostasis in the tumor microenvironment