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437,438,439 While primarily acting as a tumor suppressor, cellular senescence also plays a critical role in tissue repair, promoting localized fibrosis and immune cell recruitment to clear damaged and senescent cells

Interestingly, individual tumour-bearing mice exhibited an increase in circulating formate with disease progression while healthy mice did not show such an increase over time

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[Google Scholar] Darbonne WC, Rice GC, Mohler MA